MHC and non-MHC-restricted recognition of filarial surface antigens in mice transplanted with adult Brugia malayi parasites.
Identifieur interne : 00D999 ( Main/Exploration ); précédent : 00D998; suivant : 00DA00MHC and non-MHC-restricted recognition of filarial surface antigens in mice transplanted with adult Brugia malayi parasites.
Auteurs : G E Kwan-Lim [Royaume-Uni] ; R M MaizelsSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 1990.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (biosynthèse), Antigènes d'helminthe (immunologie), Antigènes de surface (immunologie), Brugia (immunologie), Complexe majeur d'histocompatibilité, Déficits immunitaires (immunologie), Filariose lymphatique (immunologie), Masse moléculaire, Production d'anticorps, Souris, Technique de Western, Test ELISA, Tests aux précipitines.
- MESH :
- biosynthèse : Anticorps antihelminthe.
- immunologie : Antigènes d'helminthe, Antigènes de surface, Brugia, Déficits immunitaires, Filariose lymphatique.
- Animaux, Complexe majeur d'histocompatibilité, Masse moléculaire, Production d'anticorps, Souris, Technique de Western, Test ELISA, Tests aux précipitines.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (biosynthesis), Antibody Formation, Antigens, Helminth (immunology), Antigens, Surface (immunology), Blotting, Western, Brugia (immunology), Elephantiasis, Filarial (immunology), Enzyme-Linked Immunosorbent Assay, Immunologic Deficiency Syndromes (immunology), Major Histocompatibility Complex, Mice, Molecular Weight, Precipitin Tests.
- MESH :
- chemical , biosynthesis : Antibodies, Helminth.
- chemical , immunology : Antigens, Helminth, Antigens, Surface.
- immunology : Brugia, Elephantiasis, Filarial, Immunologic Deficiency Syndromes.
- Animals, Antibody Formation, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Major Histocompatibility Complex, Mice, Molecular Weight, Precipitin Tests.
Abstract
We describe here the genetic control of humoral responses to filarial nematode Ag elicited by live adult Brugia malayi parasites in mice. Inbred and congenic mice of two different MHC haplotypes, H-2k and H-2d, were examined. Serologic analysis showed that the humoral responses to the major surface 29-kDa glycoprotein of adult parasites and a 40-kDa Ag from the surface of the microfilarial stage were restricted to mice with H-2k alleles (B10.BR, CBA/Ca, and CBA/N), whereas mice of the H-2d haplotype (B10.D2/n and BALB/c) were nonresponsive to these Ag. Conversely, internal adult Ag of molecular mass of 24 and 66 kDa were recognized only by animals with the H-2d haplotype. Apart from MHC-restricted recognition, the level of responses to phosphorylcholine and to a 15-kDa adult surface molecule were found to be influenced by non-MHC genes. A sharp restriction was also observed to an adult surface Ag complex of 17 to 200 kDa, which was recognized only by BALB/c mice. Thus, multiple examples of both H-2 and background genetic effects on the immune response to distinct filarial Ag can be found.
PubMed: 2391422
Affiliations:
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M" uniqKey="Maizels R" first="R M" last="Maizels">R M Maizels</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (biosynthesis)</term><term>Antibody Formation</term><term>Antigens, Helminth (immunology)</term><term>Antigens, Surface (immunology)</term><term>Blotting, Western</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Immunologic Deficiency Syndromes (immunology)</term><term>Major Histocompatibility Complex</term><term>Mice</term><term>Molecular Weight</term><term>Precipitin Tests</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (biosynthèse)</term><term>Antigènes d'helminthe (immunologie)</term><term>Antigènes de surface (immunologie)</term><term>Brugia (immunologie)</term><term>Complexe majeur d'histocompatibilité</term><term>Déficits immunitaires (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Masse moléculaire</term><term>Production d'anticorps</term><term>Souris</term><term>Technique de Western</term><term>Test ELISA</term><term>Tests aux précipitines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>Antigens, Surface</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Antigènes de surface</term><term>Brugia</term><term>Déficits immunitaires</term><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Immunologic Deficiency Syndromes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody Formation</term><term>Blotting, Western</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Major Histocompatibility Complex</term><term>Mice</term><term>Molecular Weight</term><term>Precipitin Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Complexe majeur d'histocompatibilité</term><term>Masse moléculaire</term><term>Production d'anticorps</term><term>Souris</term><term>Technique de Western</term><term>Test ELISA</term><term>Tests aux précipitines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We describe here the genetic control of humoral responses to filarial nematode Ag elicited by live adult Brugia malayi parasites in mice. Inbred and congenic mice of two different MHC haplotypes, H-2k and H-2d, were examined. Serologic analysis showed that the humoral responses to the major surface 29-kDa glycoprotein of adult parasites and a 40-kDa Ag from the surface of the microfilarial stage were restricted to mice with H-2k alleles (B10.BR, CBA/Ca, and CBA/N), whereas mice of the H-2d haplotype (B10.D2/n and BALB/c) were nonresponsive to these Ag. Conversely, internal adult Ag of molecular mass of 24 and 66 kDa were recognized only by animals with the H-2d haplotype. Apart from MHC-restricted recognition, the level of responses to phosphorylcholine and to a 15-kDa adult surface molecule were found to be influenced by non-MHC genes. A sharp restriction was also observed to an adult surface Ag complex of 17 to 200 kDa, which was recognized only by BALB/c mice. Thus, multiple examples of both H-2 and background genetic effects on the immune response to distinct filarial Ag can be found.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Maizels, R M" sort="Maizels, R M" uniqKey="Maizels R" first="R M" last="Maizels">R M Maizels</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kwan Lim, G E" sort="Kwan Lim, G E" uniqKey="Kwan Lim G" first="G E" last="Kwan-Lim">G E Kwan-Lim</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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